Cloxacillin

C. diff Risk

Medium

Oral Bioavailability

None

Approximate Cost

$10/day

Dosing

100-200 mg/kg/24h IV divided q4-6h (q4h dosing for CNS infections)
Maximum: 12 g/24h and Maximum: 2000 mg/dose
Dosing applies to cystic fibrosis patients

0 to 2 kgGreater than 2 kg25-50 mg/kg/dose IV q12h25-50 mg/kg/dose IV q8hHigher doses in range are used in meningitis

0 to 2 kgGreater than 2 kg25-50 mg/kg/dose IV q8h25-50 mg/kg/dose IV q6hHigher doses in range are used in meningitis

For oral therapy: consider oral cephalexin as alternative as oral cloxacillin is poorly absorbed and must be administered on an empty stomach in frequent doses.

General Information

Common Usage

Treatment of sensitive MSSA and CoNS infections

Drug Monitoring

Renal and hepatic function
CBC with differential
Diarrhea

Adverse Effects

  • allergy (immediate or delayed)

  • phlebitis (IV)

  • cytopenias

  • eosinophilia

  • interstitial nephritis

  • abnormal liver enzymes

Pharmacology

Antimicrobial class: Antistaphylococcal penicillin

Average serum half life: Adults: 0.5-1.5 h (prolonged in renal impairment and in neonates)

Route of Elimination: urine and feces