C. diff Risk


Oral Bioavailability


Approximate Cost


Spectrum Of Activity


10-20 mg/kg/dose PO BID

10-15 mg/kg/dose PO daily

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Common Usage

Therapy of streptococcal, enterococcal infections as well as susceptible gram negative infections.

Commonly used for upper respiratory infections and urinary tract infection (when organisms susceptible)

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Cytopenias

  • EBV related rash (not allergy)

Oral Liquids

Concentration: 50 mg/mL
Taste: very palatable
Not all strengths of oral liquids are listed nor are available on IWK formulary

Tablet/Capsule Strengths

250 mg capsule 500 mg capsule
Tablets and capsules are preferred especially over an unpleasant tasting liquid. Not all strengths of oral tablets/capsules are listed and they are not all available on the IWK formulary.


Antimicrobial class: Aminopenicillin

Average serum half life: Neonates, full-term: 3.7 hours
Infants and children: 1 to 2 hours

Route of Elimination: Renal excretion (60% unchanged drug)