C. diff Risk


Oral Bioavailability


Approximate Cost


Spectrum Of Activity

General Information

Common Usage

  • Lyme disease

  • Skin and soft tissue infection

  • Methicillin resistant staphylococcus aureus infections

Adverse Effects

  • GI upset (take with food to avoid)

  • Erosive esophagitis (drink plenty of water with dose)

  • Photosensitivity rash

Major Interactions

Divalent cations- decreased absorption therefore recommended to space by 2 hours.

Tablet/Capsule Strengths

100 mg tablet (scored in quarters)
Tablets and capsules are preferred especially over an unpleasant tasting liquid.
Not all strengths of oral tablets/capsules are listed and they are not all available on the IWK formulary

Additional Information

Take with food to reduce GI upset.
Avoid iron, magnesium, calcium for at least two hours before or two hours after doxycycline administration.

Contraindicated in pregnancy; except for single dose (see Lyme Disease in pregnancy) and not routinely recommended in children <8 years of age except for treatment and prophylaxis for Lyme disease (see Lyme Disease pediatrics)


Antimicrobial class: Tetracycline

Average serum half life: No data for pediatrics.
Adults: 12 to 15 hours (usually increases to 22 to 24 hours with multiple dosing)

Route of Elimination: In the urine (23%) and feces (30%)