Penicillin VK (oral)

C. diff Risk


Oral Bioavailability


Approximate Cost


Spectrum Of Activity


Use with caution; excretion is prolonged in patients with renal impairment. Consult with a pharmacist for dosing in renal impairment.

General Information

Common Usage

  • Streptococcal infections and therapy of documented susceptible infection not requiring parenteral therapy (i.e. upper respiratory tract)

  • Prophylaxis for asplenia

  • Rheumatic fever

Drug Monitoring

Monitor for allergy

Adverse Effects

  • Allergy (anaphylaxis) and other rash

  • Cytopenias, Positive Coombs, Eosinophilia

  • Serum sickness

  • Acute interstitial nephritis

Oral Liquids

Concentration: 60 mg/mL
Taste: not very palatable, unpleasant taste
Not all strengths of oral liquids are listed nor are available on IWK formulary

Tablet/Capsule Strengths

300 mg tablet
Tablets and capsules are preferred especially over an unpleasant tasting liquid.
Not all strengths of oral tablets/capsules are listed and they are not all available on the IWK formulary.


Antimicrobial class: Penicillin

Average serum half life: No pediatric data. Adults: 30 minutes; prolonged in patients with renal impairment

Route of Elimination: Penicillin V and its metabolites are excreted in urine