Piperacillin-Tazobactam

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$30/day

Dosing

Dosing is based on the piperacillin component

3 grams* IV q6h
*Injection 3/ 0.375 g vial containing: 3 g piperacillin and 0.375 g tazobactam

4 grams* IV q8h
*Injection 4/ 0.5 g vial containing: 4 g piperacillin and 0.5 g tazobactam

Dosing is based on the piperacillin component

Post natal age less than or equal to 28 daysPost natal age greater than or equal to 29 days50-100 mg/kg/dose IV q12h50-100 mg/kg/dose IV q8h

Post natal age less than or equal to 14 daysPost natal age greater than or equal to 15 days50-100 mg/kg/dose IV q12h50-100 mg/kg/dose IV q8h

Post natal age less than or equal to 7 daysPost natal age greater than or equal to 8 days50-100 mg/kg/dose IV q12h50-100 mg/kg/dose IV q8h

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Common Usage

Broad spectrum agent with anti-pseudomonal activity used for severe infections including:

  • Intra-abdominal sepsis

  • Post Partum Sepsis

  • Febrile neutropenia

Drug Monitoring

  • Renal and hepatic function

  • CBC with differential

  • C. difficile-associated diarrhea

  • Hypersensitivity reactions

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Cytopenias- esp. thrombocytopenia, eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes