Meropenem

Restricted
C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$28/day

Dosing

20 mg/kg/dose IV q8h
Maximum: 1000 mg/dose

40 mg/kg/dose IV q8h
Maximum: 2000 mg/dose

Post natal age less than or equal to 7 daysPost natal age greater than or equal to 8 days20 mg/kg/dose IV q12h20-30 mg/kg/dose IV q8h

Post natal age less than or equal to 7 daysPost natal age greater than or equal to 8 days40 mg/kg/dose IV q12h40 mg/kg/dose IV q8h

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing

General Information

Common Usage

  • Multidrug-resistant gram-negative infection of the lower respiratory tract, urinary tract, intra-abdominal, gynecologic, bone and joint, septicemias, endocarditis, and CNS

  • Treatment of multiple organism infection in which other agents have an insufficient spectrum of activity or are contraindicated due to toxic potential

  • Therapeutic alternative for treatment of gram-negative sepsis in immunocompromised patients.

Drug Monitoring

  • Renal and hepatic function

  • CBC

Adverse Effects

  • GI upset

  • Rash

  • Decrease blood counts, cytopenias, bone marrow suppression

  • Hepatic dysfunction

Pharmacology

Antimicrobial class: Carbapenem

Average serum half life: Prolonged with renal insufficiency

Route of Elimination: Primarily renal