Metronidazole - Neonatal Dosing

There is a wide variety of dosage recommendations in the literature

15 mg/kg/dose IV/PO x 1 dose

Begin maintenance dose at appropriate dosing interval as outlined in table below (i.e. if loading dose is given at 0800 h, maintenance dose would be due at 1600 h if interval is q8h or 2000 h if interval is q12h, etc.).

Corrected gestational age less than or equal to 27 weeks

7.5 mg/kg/dose IV/PO q24h

Corrected gestational age 28 to 33 weeks

7.5 mg/kg/dose IV/PO q12h

Corrected gestational age 34 to 39 weeks

7.5 mg/kg/dose IV/PO q8h

Corrected gestational age 40 to 44 weeks

10 mg/kg/dose IV/PO q8h