Clostridium difficile


Contact Precautions

General Information

Anaerobic spore forming gram positive bacilli, box-car shaped

Nosocomial > community onset diarrhea usually after taking antibiotic

Can occur in outbreaks.

Recurrence is very common therefore previous history of C. difficile is a risk factor. Antacids, especially proton-pump inhibitors, and chemotherapy also increase risk.

  •  Wide range of symptoms possible, and 15% are asymptomatic

  •  Profuse, watery diarrhea

  •  Pseudomembranous colitis or toxic megacolon

  •  Normal colonizer in infants