Antimicrobials
Tigecycline

Tigecycline

Restricted

Low
N/A
Nonformulary, not stocked $150/day

Spectrum of Activity

Dosing

General Information

M. abscessus, M. chelonae, M. fortuitum infections if patient can tolerate N/V

Associated with more treatment failures than alternatives and excess mortality - Black Box Warning.

Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility.

Avoid or use with caution in patients with tetracycline reactions.

GI side effects very prominent with significant nausea and vomiting. Consider premedication with ondansetron.

Rash, abnormal liver enzymes, pancreatitis.

Nonformulary, not stocked.

Requires Infectious Disease consultation.

Documented safety concerns in bacteremia especially.

Antimicrobial class: Glycylcyline derivative

Pregnancy category: D

Average serum half life: 42 hours

Biliary penetration: Therapeutic

Lung penetration: Therapeutic