Cephalexin

C difficile risk
Medium
Oral Bioavailability
Moderate
Cost
<$1/day

Dosing

CrCl <10CrCl 10 - 29500mg PO q12h500mg PO q8h

500mg PO q12h

Dose after dialysis on hemodialysis days

75 -100 mg/kg/day divided q6-8hr

1000 mg po TID

Morbid obese patient: consider 1500 mg PO TID or 1 g QID

General Information

  • ¬†Skin and soft tissue infection

  • ¬†MSSA infections

  • UTI

  • ¬†Allergy/rash (immediate or delayed)

  • ¬†Positive Coombs

  • ¬†Cytopenias

  • ¬†Eosinophilia

  • ¬†Hepatic & renal laboratory abnormalities

Increases metformin levels

Antimicrobial class: First Generation Cephalosporin.

Pregnancy category: B

Biliary penetration: Moderate

CSF penetration: Poor

Lung penetration: Moderate

Urine penetration: Therapeutic