Antimicrobials
Amoxicillin-Clavulanate

Amoxicillin-Clavulanate

Medium
Moderate
$0.50-$2.00/day

Spectrum of Activity

Dosing

General Information

Prophylaxis/treatment of bite wounds.

Polymicrobial infections of the respiratory tract or abdomen.

Skin and soft tissue infections.

For prolonged therapy, monitor liver enzymes and renal function.

  •  Allergy/rash (immediate or delayed)
  •  Note EBV related rash
  •  Cytopenias
  •  Diarrhea
  •  Hepatotoxicity due to clavulinate - usually mild, liver failure is rare.

Increased risk of rash with allopurinol

For Streptococcus pneumoniae infections use amoxicillin, NOT amoxicillin-clavulanate as the clavulanate does not add anything other than side effects in this setting.

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic