Nafcillin

C difficile risk
Medium
Oral Bioavailability
N/A
Cost
$40-50/day

Dosing

2 g IV q4h OR 12 grams continuous infusion over 24 hours

General Information

Serious MSSA infections (CNS, Endocarditis)

CBC weekly - Monitor for neutropenia

Generally reserved for the more serious MSSA infections.

More side effects and more costly than cefazolin.

Antimicrobial class: antistaphylococcal penicillin

Pregnancy category: B

Average serum half life: 0.5 to 1 hour

CSF penetration: Drug of choice for MSSA brain abscess

Route of Elimination: hepatic

No renal adjustment required