Valacyclovir

C difficile risk
None
Oral Bioavailability
Moderate
Cost
$<1-2/day

Dosing

CrCl 30-50 mL/minCrCl 10-29 mL/minCrCl < 10 and/or hemodialysis1 g q12h1 g q24h500 mg q24h

CrCl 10-29 mL/minCrCl < 10 mL/min and/or hemodialysis1 g q24h500 mg q24h

CrCl 10-29 mL/minCrCl < 10 mL/min and/or hemodialysis500 mg q24h500 mg q48h

CrCl 10-29 mL/minCrCl < 10 and/or hemodialysis500 mg q12h x 2 doses500 mg one time

1 g q8h

500 mg to 1000 mg q12h

500 mg to 1000 mg q24h

2 g q12h x 2 doses

General Information

Therapy for herpes viral infections (HSV) and varicella-zoster infections (VZV)

  •  GI upset

  •  Phlebitis

  •  Increased SCr

May diminish the efficacy of zoster live or varicella vaccine

More convenient dosing than oral acyclovir

Antimicrobial class: Antiviral, nucleoside analogue

Pregnancy category: B

Average serum half life: 3 hours

Comments: Prodrug of acyclovir. Rapidly converted from valacyclovir to acyclovir