Peramivir

Restricted
C difficile risk
None
Oral Bioavailability
N/A
Cost
See below

Dosing

CrCl 30-50 mL/minCrCl < 30 mL/minHemodialysis200 mg q24h100 mg q24h100 mg x 1 then 100 mg 2 hours after each HD session

ONLY for NPO patient600 mg IV q24h

General Information

Very very expensive. Requires ID provider approval.

  • ¬†Diarrhea

  • ¬†Vomiting

  • ¬†Constipation

  • ¬†Insomnia

  • ¬†Hypertension

  • ¬†AST/ALT increase

  • ¬†Alternative option: oseltamivir via ng or PO

  • ¬†Requires Infectious Diseases approval for use

Antimicrobial class: Antiviral Agent; Neuraminidase Inhibitor

Pregnancy category: Extremely limited data

Average serum half life: 20 hours