Nitrofurantoin

C. diff Risk

Low

Oral Bioavailability

Excellent

Spectrum Of Activity

Dosing

100 mg PO BID (MacroBID)

30+ mL/min0 - 29 mL/min100 mg PO BIDAVOID

General Information

Adverse Effects

Interstitial pneumonitis and fibrosis esp. with prolonged use

Peripheral neuropathy

Common Usage

DO NOT use for pyelonephritis or bacteremia as insufficient systemic drug levels.

Major Interactions

Antacids decrease absorption

Pharmacology

Pregnancy category: B

Urine penetration: Therapeutic

Lung penetration: None

CSF penetration: None

Biliary penetration: None