Piperacillin-Tazobactam

C. diff Risk

Medium

Oral Bioavailability

NA

Spectrum Of Activity

Dosing

Standard dose: 3.375 g IV q6hPseudomonas: 4.5 g IV q6h

40+ mL/min20 - 40 mL/min0 - 20 mL/min3.375 g IV q6h2.25 g IV q6h2.25 g IV q8h

40+ mL/min20 - 40 mL/min0 - 20 mL/min4.5 g IV q6h3.375 g IV q6h2.25 g IV q6h

Standard dose: 2.25 g IV q12h - give dose after dialysis on dialysis days

Pseudomonas: 2.25 g IV q8h - give dose after dialysis on dialysis days

Standard dose: 3.375 g IV q6h

Pseudomonas: 3.375 g IV q6h

Standard dose: 2.25 g IV q12h

Pseudomonas: 2.25 g IV q8h

General Information

Additional Information

Higher doses required for antipseudomonal coverage (4.5 g IV q6h)

Adverse Effects

Allergy/rash (immediate or delayed), cytopenias- esp. thrombocytopenia, eosinophilia, interstitial nephritis, abnormal liver enzymes

Major Interactions

Incr. levels of methotrexate

Pharmacology

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor

Pregnancy category: B