Cefotaxime

C. diff Risk

High

Oral Bioavailability

NA

Spectrum Of Activity

Dosing

2 g IV q8h

25+ mL/min10 - 25 mL/min<10 mL/min 2 g IV q8h2 g IV q12h2 g IV q24h

Give after dialysis on dialysis days2 g IV q24h

2 g IV q8h

1 g IV q24h

General Information

Adverse Effects

Rash, localized phlebitis at injection site, allergy.

Positive Coombs test, neutropenia, abnormalities in liver enzymes.

Diarrhea and CDI.

Pharmacology

Antimicrobial class: 3rd Generation Cephalosporin

Pregnancy category: B