Cloxacillin

C. diff Risk

Medium

Oral Bioavailability

NA

Spectrum Of Activity

Dosing

500 mg PO QID

2 g IV q4h

No dose adjustment

General Information

Adverse Effects

Allergy (immediate or delayed), Phlebitis at injection site in a peripheral vein, cytopenias, eosinophilia, interstitial nephritis, abnormal liver enzymes.

Common Usage

Treatment of MSSA infections

Major Interactions

Can increase methotrexate levels

Decrease mycophenolate levels

Pharmacology

Antimicrobial class: Antistaphylococcal penicillin

Pregnancy category: B

Average serum half life: 1.0