0.3-1.0 mg/kg IV q24h
NOTE: Do not mistake for lipid associated Amphotericin B, formulations are NOT interchangeable.
No dose adjustment
Infectious Diseases consultation recommended.
CBC, K, HCO3, Mg, liver profile.
Infusion related symptoms are common: fever/rigors/N/V/headache. They usually diminish with subsequent doses.
Electrolyte abnormalities - hypoK and hypoMg, renal tubular acidosis
Main concern is concomitant nephrotoxins - use should be minimized during amphotericin therapy
Digoxin - increased digoxin toxicity with hypokalemia
Careful attention to electrolyte and fluid status with boluses (usually 500 mL) of NS before and after infusion, as well as K and Mg supplementation as needed.
If high risk of renal toxicity, consider liposomal amphotericin B formulation.
Antimicrobial class: Antifungal - polyene
Pregnancy category: B