Ciprofloxacin
Renal

Renal

Not On Dialysis: PO Dosing (CrCl)

≥30 mL/min

500-750 mg PO BID

10 to 30 mL/min

500-750 mg PO daily

0 to 10 mL/min

250-500 mg PO daily

Not On Dialysis: IV Dosing (CrCl)

Standard Dose
  • CrCl >30 mL/min: 400 mg IV q12h
  • CrCl 0 to 30 mL/min: 400 mg IV q24h
High Dose (indicated for coverage for Pseudomonas & bone and joint infections)
  • CrCl >30 mL/min: 400 mg IV q8h
  • CrCl 0 to 30 mL/min: 400 mg IV q12h

Intermittent Hemodialysis (thrice weekly)

  • 500-750 mg PO q24h (give after dialysis on dialysis days)
  • 400 mg IV q24h (give dose post HD on HD days)

Peritoneal Dialysis

  • 500-750 mg PO q24h
  • 400 mg IV q24h

CVVHDF

400 mg IV q12h