Cefuroxime

C. diff Risk

Medium

Oral Bioavailability

Moderate

Spectrum Of Activity

Dosing

500 mg PO BID

750 mg IV q8h

30+ mL/min10 - 30 mL/min0 - 10 mL/min500 mg BID500 mg daily500 mg q48h

20+ mL/min10 - 20 mL/min0 - 10 mL/min750 mg q8h750 mg q12h750 mg q24h

500 mg PO q48h + 500 mg PO after-dialysis

750 mg IV q24h - give after dialysis on dialysis days

1 g IV q12h

500 mg PO q24h

750 mg IV q24h

General Information

Adverse Effects

Allergy (immediate & delayed), positive Coombs, cytopenias, GI upset, diarrhea, abnormal liver enzymes.

Major Interactions

None significant

Pharmacology

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B