Infectious Disease consultation recommended.
Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection.
Myopathy including rhabdomyolysis, GI side effects common, rash, phlebitis, increased INR.
Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC>=2) and VRE including endovascular infection.
Creatine kinase weekly.
Statins and fibrates: monitor creatine kinase or hold while on daptomycin therapy (increased myopathy).
Antimicrobial class: Cyclic lipopeptide, depolarizes bacterial cell membrane
Pregnancy category: B