Acyclovir

C. diff Risk

None

Oral Bioavailability

NA

Spectrum Of Activity

Dosing

HSV: 400 mg PO TID

VZV: 800 mg PO 5 times per day

10 mg/kg IV q8h (Dose by adjusted body weight if BMI 30 or greater)

10+ mL/min<10 mL/min or HD PD 400 mg PO TID400 mg PO BID - give dose after dialysis on dialysis days400 mg PO BID

25+ mL/min10 - 25 mL/min<10 mL/min or HD PD 800 mg PO 5 times per day800 mg PO TID800 mg PO BID - give dose after dialysis on dialysis days800 mg PO BID

50+ mL/min25 - 50 mL/min10 - 24 mL/min<10 mL/min or HD CVVHDF PD 10 mg/kg q8h10 mg/kg q12h10 mg/kg q24h5 mg/kg q24h - give dose after dialysis on dialysis days10 mg/kg q12h5 mg/kg q24h

General Information

Adverse Effects

GI upset, phlebitis- common

Increased SCr, AKI from crystal nephropathy

Major Interactions

Mycophenolate can increase the acyclovir concentration

May diminish efficacy of zoster or varicella vaccine

Pharmacology

Antimicrobial class: Antiviral, nucleoside analogue

Pregnancy category: B