Oseltamivir

C. diff Risk

None

Oral Bioavailability

Excellent

Dosing

Treatment: 75 mg PO BID x 5 days

Prophylaxis: 75 mg PO daily x 10 days

Duration may be extended in select circumstances.

60+ mL/min30 - 60 mL/min10 - 30 mL/min0 - 10 mL/min75 mg PO BID30 mg PO BID30 mg PO daily75 mg PO once

60+ mL/min30 - 60 mL/min10 - 30 mL/min75 mg PO daily30 mg PO daily30 mg PO every other day

Treatment: 75 mg PO qHD
Prophylaxis: 30 mg PO qHD

Treatment: 30 mg PO once
Prophylaxis: 30 mg once or qWeekly

General Information

Additional Information

Higher doses have not been shown to be superior but may be considered in critically ill or obese patients i.e. 150mg PO BID.

Adverse Effects

  • GI upset common

  • Rare - Stevens Johnson

  • Neuropsychiatric side effects reported

Common Usage

Treatment and prophylaxis of influenza

Major Interactions

No significant

Pharmacology

Antimicrobial class: Antiviral - neuraminidase inhibitor

Pregnancy category: C