Cefazolin

C. diff Risk

Medium

Oral Bioavailability

NA

Dosing

1-2 g IV q8h

35+ mL/min10 - 34 mL/min0 - 10 mL/min1-2 g IV q8h1-2 g IV q12h1 g IV q24h

Give after dialysis on dialysis days 2 g IV qHD or 1 g IV q24h

2 g IV q12h

500 mg q12h

General Information

Adverse Effects

Allergy (immediate or delayed).

Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.

Common Usage

Skin and soft tissue infection (i.e. cellulitis).

Surgical prophylaxis.

Susceptible Staphylococcal, Streptococcal and Gram negative infections.

Major Interactions

Probenecid prolongs the half-life of cefazolin allowing it to be used for once daily therapy. This usage is limited to once daily outpatient parenteral antimicrobial therapy. Inpatient usage not recommended.

Pharmacology

Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B