Careful attention to electrolyte and fluid status with boluses (usually 500 mL) of NS before and after infusion, as well as K and Mg supplementation as needed.
Same toxicities as conventional Amphotericin B but with less frequency.
Infusion related symptoms are common: fever/rigors/N/V/headache. They usually diminish with subsequent doses.
Electrolyte abnormalities - hypoK and hypoMg, renal tubular acidosis.
Infectious Diseases consultation recommended.
CBC, K, HCO3, Mg, liver profile.
Main concern is concomitant nephrotoxins - use should be minimized during amphotericin therapy.
Digoxin - increased digoxin toxicity with hypokalemia.
Antimicrobial class: Antifungal - polyene - Lipid formulations (designed to minimize toxicity)
Pregnancy category: B