Imipenem

Restricted
C. diff Risk

Medium

Oral Bioavailability

NA

Spectrum Of Activity

Dosing

500 mg IV q6h

70+ mL/min30 - 70 mL/min21 - 30 mL/min0 - 20 mL/min500 mg IV q6h500 mg IV q6-8h500 mg IV q8-12h250-500 mg IV q12h

Give dose after dialysis on dialysis days250-500 mg IV q12h

1000 mg IV load, then 500 mg IV q6h

250 mg IV q12h

General Information

Adverse Effects

Immediate and delayed-type allergy

GI disturbance

Cytopenias, positive Coombs

Liver enzyme abnormalities

CNS effects including confusional states and seizures

Major Interactions

May decrease serum concentrations of valproic acid

Ganciclovir/valganciclovir - may increase risk of seizures

Cyclosporine - may enhance neurotoxic effects of Imipenem

Pharmacology

Antimicrobial class: Carbapenem

Pregnancy category: C