Meropenem

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C. diff Risk

Medium

Oral Bioavailability

NA

Dosing

Standard dose: 500 mg IV q6hHigh dose: 2000 mg IV q8h

50+ mL/min25 - 49 mL/min10 - 24 mL/min0 - 10 mL/min500 mg IV q6h500 mg IV q8h500 mg IV q12h500 mg IV q24h

50+ mL/min10 - 50 mL/min0 - 10 mL/min2000 mg IV q8h2000 mg IV q12h2000 mg IV q24h

Standard dose: 500 mg IV q24h - give after dialysis on dialysis days

High dose: 2000 mg IV q24h - give after dialysis on dialysis days

Standard dose: 500 mg IV q6h

High dose: 1000 mg IV q8h

Standard dose: 500 mg IV q24h

High dose: 2000 mg IV q24h

General Information

Adverse Effects

Immediate and delayed-type allergy

GI disturbanceCytopenias, positive Coombs

Liver enzyme abnormalities

Major Interactions

Valproic acid - carbapenems decrease valproate levels and may decrease seizure threshold

Pharmacology

Antimicrobial class: carbapenem

Pregnancy category: B