Amoxicillin-Clavulanate

C. diff Risk

Medium

Oral Bioavailability

Excellent

Dosing

875-125 mg one tab PO BID
OR 500-125 mg one tab PO TID

30+ mL/min0 - 30 mL/min875-125 mg one tab PO BIDAVOID - use 500-125 mg tab

30+ mL/min10 - 30 mL/min<10 mL/min or HDPD500-125 mg one tab PO TID500-125 mg one tab PO BID500-125 mg one tab PO BID - take after dialysis on HD days500-125 mg one tab PO BID

General Information

Adverse Effects

Hepatotoxicity due to clavulanate - usually mild, liver failure is rare

Allergy/rash (immediate or delayed), cytopenias, diarrhea. Note EBV related rash.

Major Interactions

Increased risk of rash with allopurinol

Pharmacology

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B