Ampicillin

C. diff Risk

Low

Oral Bioavailability

NA

Dosing

1 g IV q6h (standard dose)

2 g IV q4h (high dose for meningitis or endocarditis)

10+ mL/min<10 mL/min or HD CVVHDF PD 1 g IV q6h1 g IV q12h - give dose after dialysis on dialysis days1 g IV q8h1 g IV q12h

50+ mL/min10 - 50 mL/min<10 mL/min or HD CVVHDF PD 2 g IV q4h2 g IV q6h2 g IV q12h - give dose after dialysis on dialysis days2 g IV q6h1 g IV q12h

General Information

Adverse Effects

Allergy and rash as for all beta-lactams
EBV related rash (not allergy)
Rare: cytopenias, +ve Coombs

Major Interactions

Increased risk of rash with allopurinol

Pharmacology

Antimicrobial class: aminopenicillin

Pregnancy category: B