Colistin - Renal Dosing

Dosing expressed in colistin base activity

Obese patients are dosed according to Dosing Body Weight (DBW).

Consult pharmacist or refer to "Additional Information" section for details.

CrCl ≥90 mL/min

Initial Loading Dose: 300 mg IV load, then
Maintenance Dose: 180 mg IV Q12H

CrCl 80 to <90 mL/min

Initial Loading Dose: 300 mg IV load, then
Maintenance Dose: 170 mg IV Q12H

CrCl 70 to <80 mL/min

Initial Loading Dose: 300 mg IV load, then
Maintenance Dose: 150 mg IV Q12H

CrCl 60 to <70 mL/min

Initial Loading Dose: 300 mg IV load, then
Maintenance Dose: 138 mg IV Q12H

CrCl 50 to <60 mL/min

Initial Loading Dose: 300 mg IV load, then
Maintenance Dose: 122 mg IV Q12H

CrCl 40 to <50 mL/min

Initial Loading Dose: 300 mg IV load, then
Maintenance Dose: 110 mg IV Q12H

CrCl 30 to <40 mL/min

Initial Loading Dose: 300 mg IV load, then
Maintenance Dose: 98 mg IV Q12H

CrCl 20 to <30 mL/min

Initial Loading Dose: 300 mg IV load, then
Maintenance Dose: 88 mg IV Q12H

CrCl 10 to <20 mL/min

Initial Loading Dose: 300 mg IV load, then
Maintenance Dose: 80 mg IV Q12H

CrCl 5 to <10 mL/min

Initial Loading Dose: 300 mg IV load, then
Maintenance Dose: 72 mg IV Q12H

CrCl 0 mL/min

Initial Loading Dose: 300 mg IV load, then
Maintenance Dose: 65 mg IV Q12H

Initial Loading Dose: 300 mg IV load, then
Maintenance Dose: 65 mg IV Q12H

Post-dialysis supplemental doses

3-hour IHD run

  • Supplement an additional 40 mg at end of dialysis run

4-hour IHD run

  • Supplement an additional 50 mg at end of dialysis run

Initial Loading Dose: 300 mg IV load, then
Maintenance Dose: 220 mg IV Q12H

Initial Loading Dose: 300 mg IV load, then
Maintenance Dose: 150-200 mg IV daily