Cotrimoxazole

C. diff Risk

Low

Oral Bioavailability

Excellent

Spectrum Of Activity

Dosing

Routine indications: 1-2 DS tab PO BID
(Note: DS = 160 mg TMP, SS = 80 mg TMP)

High dose therapy: 5 mg/kg IV q6h (dosing based on TMP component)

30+ mL/min0 - 30 mL/min1-2 DS tab PO BID1-2 DS tab PO daily

30+ mL/min10 - 30 mL/min0 - 10 mL/min5 mg/kg IV q6h5 mg/kg IV q12h5-10 mg/kg IV q24h

1-2 DS tab PO daily - Give after dialysis on dialysis days.

5-10 mg/kg IV q24h - Give after dialysis on dialysis days.

5-10 mg/kg IV q12h

1 SS to 1 DS tab PO BID

5-10 mg/kg IV q24h

General Information