Clostridium difficile


Contact Precautions
Contact Precautions

General Information

Pathogen information

Anaerobic spore forming gram positive bacilli, box-car shaped


Clostridium difficile-associated diarrhea usually after taking antibiotics.

Can occur in outbreaks.

Recurrence is very common therefore previous history of C. difficile is a risk factor.

Antacids, especially proton-pump inhibitors, and chemotherapy also increase risk.

Associated syndromes

Wide range of symptoms possible, and 15% are asymptomatically colonized.

Profuse, watery diarrhea

Pseudomembranous colitis or toxic megacolon

Normal colonizer in infants

Additional Information

Consider fecal microbiota transplant (FMT) in recurrent or refractory disease.