Useful Tools
Procedure for Amoxicillin/Penicillin Challenge

Procedure for Amoxicillin/Penicillin Challenge

1) Obtain consent from patient for oral challenge.

2) Give 1/10th dose of the intended antibiotic or a single dose oral challenge of amoxicillin 500mg x 1 (supervised by RN).

3) Observe patients for at least 60 minutes for any immediate hypersensitivity reaction. Check vital signs at baseline and every 30 minutes x 2 after the first dose.

Anaphylaxis Quick Reference:

4) Follow up oral challenge and document outcome of oral challenge in chart. If no reaction observed, proceed with full treatment dose.

5) If no reaction observed, document in EMR (under allergies) that patient tolerated oral challenge of antibiotic.

6) If no reaction observed and allergy is documented on Pharmanet profile, de-label the allergy using the “Request to Inactivate Adverse Reaction/Clinical Condition” form.

7) Monitor patient throughout stay for any delayed hypersensitivity.