e.g., GI intolerance, Diarrhea, Headache
e.g., Morbilliform rashes (in absence of pruritus) are not typical of type I reactions
Poorly described symptoms (no hospitalization, no systemic involvement, occurred >10 yrs ago)
e.g., angioedema, urticarial/pruritus, laryngeal edema, wheezing, hypotension.
Poorly described symptoms but patient has poorly controlled and/or unstable cardiac or respiratory comorbidity.
Impacts all Penicillins:
Drug-Specific:
Drug-induced hemolytic anemia, thrombocytopenia, agranulocytosis, and neutropenia are drug-specific. Cross-reactivity between cephalosporins and penicillins does not appear to occur. Avoid the offending drug.