Acute simple cystitis
Acute UTI confined to the bladder:
Dysuria, frequency, urgency, hematuria, and/or suprapubic pain
No signs or symptoms of upper tract or systemic infection.
Acute complicated UTI
Acute UTI accompanied by signs or symptoms of extension of infection beyond bladder (acute pyelonephritis, febrile UTI, or catheter-associated UTI):
Fever, chills, rigors, significant fatigue or malaise, nausea, vomiting
Flank pain, CVA tenderness
Pelvic or perineal pain in men
Patients may or may NOT have cystitis symptoms.
Bacteremic UTI and “urosepsis” are managed the same as acute complicated UT
Special populations with unique features
Renal transplant recipients
Acute Simple Cystitis
Acute Complicated UTI
Oral regimen preferred from outset in most patients.
If started on parenteral agent, switch to oral agent as soon as feasible.