Guidelines
Colistin Dosing

Colistin Dosing

Pharmacology

The pharmacologic target for colistin is an average steady-state plasma concentration of 2 mg/L (Css,avg)

The susceptibility breakpoint for colistin for Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter is less than or equal to 2 mg/L

  • Colistin doses in the scientific literature may be expressed in different ways. The conversion is as follows:

    • 1 million International Units of Colistin = 33 mg of Colistin Base Activity (CBA) = 80 mg of colistimethate (CMS)
  • All doses for Colistin should be expressed in Colistin Base Activity