Empiric antibiotics should be reassessed after 48 hours in light of clinical progress, investigations, and microbiology results.
MRSA Risk Factors
Prior MRSA colonization/infection
Intravascular or urinary catheter
Recent broad-spectrum antibiotic exposure.
ESBL Risk Factors
Prior ESBL colonization/infection
Recent broad-spectrum antibiotic exposure
The risk of serious cross-reaction in penicillin/cephalosporin allergic patients given carbapenems is very low.
In most patients with sepsis or septic shock, the potential benefits of carbapenem therapy outweigh the low risk of anaphylaxis.
Intra-Abdominal or Hepatobiliary
POTENTIAL SEPSIS without life-threatening organ dysfunction
SEPSIS with life-threatening organ dysfunction