Asymptomatic C. difficile colonization
Stool testing positive for toxigenic C. difficile without symptoms of C. difficile infection. This does not require any treatment – up to 10% of the population asymptomatically carries toxigenic C. difficile
Suspected CDI case
Acute onset of diarrhea (3 or more loose stools in 24 hours) above patient’s baseline and not attributed to another cause.
Send stool for C. difficile testing
Consider starting empiric treatment if potentially severe disease (WBC greater than 15 or creatinine greater than 133) or fulminant disease
Confirmed CDI case
Acute onset diarrhea (3 or more loose stools in 24 hours) above patient’s baseline and not attributed to another cause.
AND ANY ONE OF:
Stool testing positive for toxigenic C. difficile
Pseudomembraneous colitis on endoscopy or histopathology
Initial Episode CDI
Not meeting criteria for fulminant CDI
General measures for all CDI cases