Oral Step-Down

Oral step-down can occur when patient is clinically improving and without systemic toxicity

Osteomyelitis

If osteomyelitis is diagnosed, oral step-down can be considered using agents with good oral bioavailability:

Note

If oral step-down is not possible because of severity, intolerance, or resistance, then intravenous therapy should be continued; consider transition to outpatient parenteral antimicrobial therapy