3-7 days sufficient for the vast majority of VAP
7 days likely sufficient for most Pseudomonas VAP
While clinical trials suggest higher recurrence with 7 vs 14 days for Pseudomonas VAP, recurrence as defined in trials is of uncertain clinical significance. Short-course therapy has similar mortality, mechanical ventilation, and critical care unit length of stay compared to long-course therapy.
Without S. aureus bacteremia: 7 days
With S. aureus bacteremia: Minimum 14 days (ID Consult recommended)