Enhance nephrotoxic effect with concomitant use of other nephrotoxins - use should be minimized during amphotericin therapy
Premedication with acetaminophen, diphenhydramine, or hydrocortisone for infusion related symptoms
Antimicrobial class: Antifungal - polyene
Average serum half life:
Route of Elimination: Urine (2% to 5% unchanged); ~40% eliminated over 7-day period and may be detected in urine for up to 8 weeks after discontinued use