Antimicrobials
Amphotericin B Deoxycholate

Amphotericin B Deoxycholate

Low
N/A
$$$

Spectrum of Activity

General Information

  • Fungicidal therapy of yeast/fungus/mold infection, especially of the urinary tract as lipid formulations are otherwise preferred to minimize toxicity
  • Induction therapy for dimorphic fungii (cocci, blasto, histo)
  • Renal function, fluid status, serum electrolytes (K, Mg)
  • Liver enzymes, CBC with differential
  • Infusion related symptoms: Fever/rigors/N/V/headache
  • Electrolyte abnormalities - hypokalemia and hypomagnesemia, loss of bicarb
  • Nephrotoxicity ++
  • Anemia
  • Phlebitis

Enhance nephrotoxic effect with concomitant use of other nephrotoxins - use should be minimized during amphotericin therapy

Premedication with acetaminophen, diphenhydramine, or hydrocortisone for infusion related symptoms

Antimicrobial class: Antifungal - polyene

Average serum half life:

  • Premature neonates (GA: 27.4 ± 5 weeks): 14.8 hours (range: 5 to 82 hours)
  • Infants and Children (4 months to 14 years): 18.1 ± 6.6 hours (range: 11.9 to 40.3 hours)

Route of Elimination: Urine (2% to 5% unchanged); ~40% eliminated over 7-day period and may be detected in urine for up to 8 weeks after discontinued use